Nursing is a unique profession, which requires a commitment to provide services, that benefits individuals and the community. The aim of this paper is to illuminate the core concepts of nursing practices based on two extinguishing nursing theories namely Betty Neuman's System Model (1970) and Hildegard E. Peplau's Theory of Interpersonal Relations (Peplau, 1997). Moreover, this paper will execute a fundamental comparison and contrast between the two theories, extensively through its application in clinical practice. The four nursing meta-paradigms including person, health, environment, and nursing will be the guiding force to evaluate the applicability of both the nursing theories in the clinical scenario. In conclusion, both Neuman's and Peplau's work are pertinent to the Pakistani context, though the mixed approach of both the theories may contribute nurses to provide better comprehensive care.