i-manager Publications

Micro Robot for Wireless Capsule Endoscopy and Targeted Drug Delivery

B. Paulchamy *, P. Vijayalakshmi **, K. Mahendrakan***

*,*** Department of Electronics and Communication Engineering, Hindusthan Institute of Technology, Coimbatore, Tamil Nadu, India.

** Department of Electronics and Communications Engineering, Hindusthan College of Engineering & Technology, Coimbatore, Tamil Nadu, India.

Periodicity:August - October'2019
DOI : https://doi.org/10.26634/jic.7.4.17351

Abstract

This paper mainly describes a platform to achieve targeted drug delivery in the next-generation wireless capsule endoscopy. Targeted drug delivery helps in giving the medicine to the affected area only instead of giving it to the entire body. The major mechanism of the proposed system is the micro-positioning of the targeted medication with a level of 1 ml. This micro-positioning enables us to place the capsule in the required direction. The proposed micro-positioning mechanism allows a needle to be positioned within a 22.5° segment of a cylindrical capsule and be extendible up to 1.5mm outside the capsule body. The locomotion of the microrobot is achieved by magnetic mechanisms, which helps in holding the capsule as well as resist the peristaltic movement when necessary. The proposed infrastructure of the mechanism can be done using the combination of a single micro-motor with a volume of 200 mm³. An in-intensity evaluation of the mechanics is furnished and a top-level view of the requirements important to comprehend fashionable system integration is cited right here. This paper mainly aims to give the medication to the specified location. This will reduce the reaction of the drugs especially those drugs which are used for cancer treatment. Cancer treating drug when given through blood will reach all other organs before reaching the diseased tissue or part of the organ. Not only that, but it also helps to turn down the cost of drugs used for the cure. It is envisaged that the targeted drug delivery platform will empower a new breed of capsule microrobots for therapy in addition to diagnostics for pathologies such as ulcerative colitis and small intestinal Crohn's disease.

Keywords

Gastrointestinal (GI) Tract, Microrobot, Pill Robot, Targeted Therapy, Wireless Capsule Endoscopy.

How to Cite this Article?

Paulchamy, B., Vijayalakshmi, P., and Mahendrakan, K. (2019). Micro Robot for Wireless Capsule Endoscopy and Targeted Drug Delivery. i-manager's Journal on Instrumentation and Control Engineering, 7(4), 1-11. https://doi.org/10.26634/jic.7.4.17351

References

[1]. Carpi, F., Galbiati, S., & Carpi, A. (2007). Controlled navigation of endoscopic capsules: Concept and preliminary experimental investigations. IEEE Transactions on Biomedical Engineering, 54(11), 2028-2036.

[2]. Cave, D. R., Fleischer, D. E., Leighton, J. A., Faigel, D. O., Heigh, R. I., Sharma, V. K., ... & Lee, M. (2008). A multicenter randomized comparison of the Endocapsule and the Pillcam SB. Gastrointestinal Endoscopy, 68(3), 487- 494.

[3]. Connor, A., Evans, P., Doto, J., Ellis, C., & Martin, D. E. (2009). An oral human drug absorption study to assess the impact of site of delivery on the bioavailability of bevirimat. The Journal of Clinical Pharmacology, 49(5), 606-612.

[4]. Epstein, M. (2009). Ingestible Event Marker System—A Novel, Physiologically-Sized Device Platform for Frequent, Repeated Use. Gastrointestinal Endoscopy, 69(5).

[5]. Forgione, A. (2009). In vivo microrobots for natural orifice transluminal surgery. Current status and future perspectives. Surgical Oncology, 18(2), 121-129.

[6]. Goldfarb, N. I., Pizzi, L. T., Fuhr Jr, J. P., Salvador, C., Sikirica, V., Kornbluth, A., & Lewis, B. (2004). Diagnosing Crohn's disease: an economic analysis comparing wireless capsule endoscopy with traditional diagnostic procedures. Disease Management, 7(4), 292-304.

[7]. Gray, H. (2005). Gray's Anatomy. London: Greenwich Editions.

[8]. Meron, G. D. (2000). The development of the swallowable video capsule (M2A). Gastrointestinal Endoscopy, 52(6), 817-819.

[9]. Metzger, Y. C., Adler, S. N., Shitrit, A. B., Koslowsky, B., & Bjarnason, I. (2009). Comparison of a new PillCam™ SB2 video capsule versus the standard PillCam™ SB for detection of small bowel disease. Reports in Medical Imaging, 2(1), 7-11.

[10]. Miftahof, R. N. (2005). The wave phenomena in smooth muscle syncytia. In silico biology, 5(5, 6), 479-498.

[11]. Park, H., Park, S., Yoon, E., Kim, B., Park, J., & Park, S. (2007, April). Paddling based microrobot for capsule endoscopes. In Proceedings of 2007 IEEE International Conference on Robotics and Automation (pp. 3377- 3382). IEEE.

[12]. Rao, S. S., Kuo, B., McCallum, R. W., Chey, W. D., DiBaise, J. K., Hasler, W. L., ... & Semler, J. R. (2009). Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipation. Clinical Gastroenterology and Hepatology, 7(5), 537-544.

[13]. Swain, P., & Fritscher-Ravens, A. (2004). Role of video endoscopy in managing small bowel disease. Gut, 53(12), 1866-1875.

[14]. Toennies, J. L., Tortora, G., Simi, M., Valdastri, P., & Webster, R. J. (2010). Swallowable medical devices for diagnosis and surgery: The state of the art. Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 224(7), 1397-1414.

[15]. Valdastri, P., Webster III, R. J., Quaglia, C., Quirini, M., Menciassi, A., & Dario, P. (2009). A new mechanism for mesoscale legged locomotion in compliant tubular environments. IEEE Transactions on Robotics, 25(5), 1047- 1057.

[16]. Wilding, I., Hirst, P., & Connor, A. (2000). Development of a new engineering-based capsule for human drug absorption studies. Pharmaceutical Science & Technology Today, 3(11), 385-392. https://doi.org/10.1016/S1461- 5347(00)00311-4

[17]. Woo, S. H., Kim, T. W., & Cho, J. H. (2010). Stopping mechanism for capsule endoscope using electrical stimulus. Medical & biological engineering & computing, 48(1), 97-102. https://doi.org/10.1007/s11517-009-0553-x

[18]. Woods, S. P., & Constandinou, T. G. (2011, September). Towards a micropositioning system for targeted drug delivery in wireless capsule endoscopy. In 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 7372- 7375). IEEE.

Micro Robot for Wireless Capsule Endoscopy and Targeted Drug Delivery

Abstract

Keywords

How to Cite this Article?

References

If you have access to this article please login to view the article or kindly login to purchase the article

Purchase Instant Access

Options for accessing this content:

	North Americas,UK, Middle East,Europe		India	Rest of world
	USD	EUR	INR	USD-ROW
Online	200	35	35	200	15
Pdf	35	35	200	20
Pdf & Online	35	35	400	25