Box girder bridges are undoubtedly, one of the best options with a multitudinous number of advantages when compared to other options. The major objective of this research is to study the performance of the box girder section in determining the performance of the bridges with same widths and spans. For the purpose of this study, six box girder models (two cell and three cell girder) were analyzed for IRC Class 70R (wheeled loading) consisting of different cross-sectional properties. The performance in terms of vertical deflections and longitudinal bending stresses of these bridges with various cross-sections has been assessed. The influence of pre-stressing has also been studied and the results for one interior girder bridges were compared to those of two interior girder bridges for all different section types considered. After the numerical study of the box girder with variation of configuration (rectangular, trapezoidal and circular), the response in terms of displacement and longitudinal bending stresses of the rectangular bridge gave the minimum value when compared to trapezoidal and circular bridge in all the cases. Also, while comparing two cell and three cell box girder, the three cell girder bridges produce lesser deformations when compared to the two cell girder bridges which is due to an extra interior girder which improves the overall stiffness and structural integrity of the section.