The first AIDS case in India was reported in 1986, and as the epidemic was spreading, there was a need for nationwide efforts. Over time several successful Projects have been operated to control the epidemic. HIV Projects have successfully evolved over a timeline of last 25 years. This paper attempts to review a few such projects to assess their evolution with time and to evaluate their impact to guide other disease intervention projects for other infectious epidemics, especially in Tuberculosis (TB) and HIV TB co-infections. Effective evaluation of these projects has provided the evidence based foundation for projects over time. The methodology used for the analysis of projects was done through an exhaustive literature search, from peer-reviewed articles and international/national and Government/Non-Government Organizations' (NGO) reports. These projects have previously been successful in increasing awareness, literacy rate and effecting socio- economic empowerment of the key population. Assessing these projects has provided the best practices and approaches as key learning as compiled in this paper. Taking lessons from the HIV–AIDS projects and applying them in other projects could shorten the learning curve for other disease prevention and control.