Aggression in adolescents is identified as a significant public health issue. While aggression exists from childhood to adulthood, its incidence is significantly higher among adolescents. Aggression can be physical, verbal or relational, and differences in aggressive behaviors exist among adolescent girls and boys. Aggressive behavior has been linked with a range of different adverse effects on individual's health ranging from negative psychological health outcomes to high homicide rates. This demands understanding aggression through multi-dimensional lens to view its roots. Aggressive behavior in adolescents can be explained by taking different factors in consideration like modeling and reinforcement, parenting style, psychological maltreatment, peer relationship, genetics, and role of media. Since aggression in adolescents is a complex behavior, healthcare professional particularly nurses can use three-pronged approach for the prevention and management of aggression. This issue also demands appropriate interventions through schools and community settings like school-based social skill training.