Adolescence is defined as the years between the onset of puberty and the beginning of adulthood, during this time young children grow physically, cognitively, and emotionally, changing from a child into an adult. Adjusting to their sexually changing bodies and emerging perceptions of human relationships, as well as learning new coping and decision-making skills, are amongst the foremost responsibilities of this development phase. Puberty is reached during adolescence, which is a major landmark in the development of sexuality. During this time, sexuality education for children and adolescents plays a fundamental role in shaping their sexual and reproductive health and overall wellbeing. This paper presents a brief account of the role of parents, families, and school health curricula in providing sexuality education. Also, the role of nurses in advancing sexuality education among adolescents. Finally, the barriers and facilitators to advancing sexuality education.