Theories are the foundation for all professions. It provides set of concepts that make basic knowledge of the specific discipline. Similarly nursing theories are the set of concepts and principles that define the scientific basis of nursing profession. These theories help to differentiate between nursing practice and medical practice. Nursing theories provide a medium to rationalize the care provided by nurses. Moreover, it provides an identity to nurses that differentiate nursing practice from the medical practice. Nursing theories are considered as indicators of evidence- based nursing practices; however, researchers claim that their application is missing from the practice area. Nurses are on the verge of implementing nursing theories. They are facing many challenges and barriers in terms of understanding concepts, clarification of defined concepts for the implication, and also from the research point of view. Current literature is limited in terms of highlighting issues a nurse faces while implementing at the clinical area. More research is required to identify the challenges and barriers especially in the Pakistani context.