st century. Phyto-extracts are the major source of anti-microbial agent, responsible for killing many intracellular and extracellular microbes. These therapeutic benefits are caused by increased nitrite generation, activation of Th1 cytokine response, elevated serum chemokines and induction of reactive oxygen species. Our review highlights the important contributions of several phyto-products like artemisinin, glycyrrhizic acid, quassin, and resveratrol which have shown to be efficient against the progression and establishment of L. donovani infection. Therefore, the present study deals with a detailed account of the potentiality of immuno modulators, especially these four most widely recommended anti-leishmanial phyto-agents that gained momentum in the 21st century, including the way they carry out their mechanistic roles in parasite clearance and host healing.

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Natural Phyto-Constituents as Leishmanicides: A Brief Review of the Most Widely Recommended Phyto Chemicals of the 21st Century and an Account of their Mode of Action

Angela Perris*, Junaid Jibran Jawed **, Subrata Majumdar***
* Department of Microbiology, St. Xavier's College, Kolkata, West Bengal, India.
** Department of Life Sciences, School of Biotechnology, Presidency University, Kolkata, West Bengal, India.
*** Department of Molecular Medicine, Bose Institute, Kolkata, West Bengal, India.
Periodicity:October - December'2019
DOI : https://doi.org/10.26634/jls.1.1.16557

Abstract

Visceral Leishmaniasis (VL), a deadly form of leishmaniasis caused by Leishmania donovani, is one of the most serious threats yet neglected complication and a major arena of research of the 21st century. Phyto-extracts are the major source of anti-microbial agent, responsible for killing many intracellular and extracellular microbes. These therapeutic benefits are caused by increased nitrite generation, activation of Th1 cytokine response, elevated serum chemokines and induction of reactive oxygen species. Our review highlights the important contributions of several phyto-products like artemisinin, glycyrrhizic acid, quassin, and resveratrol which have shown to be efficient against the progression and establishment of L. donovani infection. Therefore, the present study deals with a detailed account of the potentiality of immuno modulators, especially these four most widely recommended anti-leishmanial phyto-agents that gained momentum in the 21st century, including the way they carry out their mechanistic roles in parasite clearance and host healing.

Keywords

Leishmaniasis, Artimisinin, Quassin, Glycyrrhizic Acid, Resveratrol.

How to Cite this Article?

Perris, A., Jawed, J. J., and Majumdar, S. (2019). Natural Phyto-Constituents as Leishmanicides: A Brief Review of the Most Widely Recommended Phyto Chemicals of the 21st Century and an Account of their Mode of Action. i-manager's Journal on Life Sciences, 1(1), 38-46. https://doi.org/10.26634/jls.1.1.16557

References

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[31]. Rezaei, R., Tappeh, K. H., Seyyedi, S., & Mikaili, P. (2017). The anti-leishmanial efficacy of artemisia dracunculus ethanolic extract in vitro and its effects on IFN-γ and IL-4 response. Iranian Journal of Parasitology, 12(3), 398-407.
[39]. Vang, O. (2013). What is new for resveratrol? Is a new set of recommendations necessary. Annals of the New York Academy of Sciences, 1290(1), 1-11.
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