Background: The aim of this research was to identify the basic information regarding the knowledge and practices of Family planning methods among women living in semi urban areas of Karachi, Pakistan and to derive conclusions from the research to provide necessary recommendations and suggestions which the family planning services in Pakistan can possibly implement. Methodology: We used a cross-sectional A cross-sectional design was used. This study also used purposive sampling for the selection of the participants. The developed questionnaire was pre-tested on a small portion of the population, approximately 10-15% of the total sample size. SPSS was used to interpret the data findings. Findings: The results revealed that only the factor “number of children” had a significant association with the family planning user (<0.05). For knowledge of family planning methods with their users: satisfaction with contraceptive’s effectiveness, satisfaction with contraceptive’s cost and getting awareness from family planning centers has shown to be significantly (< 0.05) associated with the family planning users. For practices; effective family planning methods, availability of contraceptives, and the cost effectiveness of methods were found highly significant with the family planning users (<0.001). Whereas, knowledge about the uses of contraceptives other than birth control was found to be independent of family planning users (>0.05). In contrast, age group, education, employment status, type of family have been found to be highly insignificant in the results (>0.05). Conclusion: Knowledge and continues practices on family planning methods for women has an enormous impact on the Family Planning process. Hence, it is important to view the impact through an active participation of community Health Care Centers and services offered by them, with increase in the resources provided, such as contraceptives,. Additionally, healthcare professionals need to be involved in awareness sessions. The approach is to move ahead, and that can be achieved only by involving men in family planning practices to create promotions of empowerment for women, rather than dependencies.