Studies on Solubility Enhancement of Telmisartan by Adsorption Method

Sharad Kamble*, Sunita Shinde**
* Department of Pharmaceutics, Nootan College of Pharmacy, Kavathe Mahankal, Sangli, Maharashtra, India.
** Department of Pharmaceutics, Tatayasaheb Kore College of Pharmacy Warnanagar, Kolhapur, Maharashtra, India.
Periodicity:October - December'2019
DOI : https://doi.org/10.26634/jchem.1.1.16370

Abstract

In this study precipitated form of Telmisartan was prepared by using Solvent evaporation technique and Spray drying technique. For this used adsorbents like Sylysia, Neusilin, and diluents like Lactose Monohydrate and Avicel. All these prepared batches were screened by performing Drug content, saturation solubility and dissolution study of the prepared batches. From this obtained optimized batch further characterized by using the dissolution test, Differential Scanning Calorimetry (DSC), X-Ray powder Diffractometer (XRD), and USP Dissolution test apparatus.

Keywords

Telmisartan, Solvent Evaporation Method, Spray Drying Technique, Adsorbent Carrier like Neusilin, Sylysia, Diluents Like Lactose Monohydrate and Avicel, Dissolution Rate.

How to Cite this Article?

Kamble, S., and Shinde, S. (2019). Studies on Solubility Enhancement of Telmisartan by Adsorption Method. i-manager's Journal on Chemical Sciences, 1(1), 17-29. https://doi.org/10.26634/jchem.1.1.16370

References

[1]. Brahmankar, D. M., & Jaiswal, S. B. (1995). Biopharmaceutics and Pharmacokinetics: A treatise. Vallabh prakashan, New Delhi, India.
[3]. Sharad, K. K., & Shinde, S. S. (2019). Formulating self phospholipids dispersion of poorly water soluble drug to enhance oral bioavailability. A review and research: Journal of Pharmaceutical Sciences.
[4]. Shashikant, M. K., Shinde, S. S., Jamakandi, V. G., & Ratan, G. N. (2011). Physiochemical Characterisation and Dissolution Studies on Solid Dispersion of Methotrexate, 1(1), 33-40.
[5]. Shinde S. S., & Avinash, H. H. (2014a). Preparation and Evaluation of Nanosuspensions for Enhancing the Dissolution of Lornoxicam by Antisolvent Precipitation Technique, 4(01), 398-405.
[6]. Shinde, S. S., & Avinash, H. H. (2014b). Preparation and evaluation lipid nanoparticles of Fenofibrate obtained by spray drying technique. Pharmacophore, 5(1), 85-93.
[7]. Shinde, S. S., & Sharad K. K. (2019). Comparative studies of various adsorbent carriers for enhancing dissolution profile of ketoprofen, european. Journal of Pharmaceutical and Medical Research, 6(10).
[8]. Shinde, S. S., Desai, R. S., Dhumal, G. J., Patki, R. S., & Mevekari, F. I. (2018). Microparticulate formulations and physicochemical evaluation of poorly water soluble drugs by using spray drying technique. International Journal Pharm Science Review and Research, 53(1), 57-61.
[9]. Shinde, S. S., Patil, M. V., Mevekari, F. I., Shete, A. S., Bhagwat, D. A., & D'souza, J. I. (2012). Physicochemical characterization and solubility enhacement of simvastatin using solid dispersion technology. World Journal of Pharmaceutical Research, 2, 297-308.
[10]. Shinde, S. S., Patil, S. S., Mevekari, F. I., & Satpute, A. S. (2010). An approach for solubility enhancement: Solid dispersion. International Journal of Advances in Pharmaceutical Sciences, 1(3).
[11]. Shinde, S. S., Shete, A. S., Manisha, V. P., & Bhushan, S. V. (2012). Different binary polymer mixture for solubility enhancement of poorly water soluble drug by solid dispersion technique. International Journal of PharmTech Research, 4(3), 1159-1166.
[12]. Shinde, S. S., Shete, A. S., Patil, M. V., Salunkhe, S., & Indapure, D. (2014). Preparation and physicochemical characterization of poorly water soluble drug by using spray drying and solvent evaporation methods. International Journal of Pharmacy & Life Sciences, 5(3). 1035-1044.
[13]. Shinde, S. S., Shete, A., Disouza, J. I., & Pranit, A. (2013). Solid dispersions of poorly water soluble drug using spray drying technique. International Journal of Drug Delivery, 5(3), 323-330.
[14]. Zhang, P., Forsgren, J., & Stromme, M. (2014). Stabilisation of amorphous ibuprofen in Upsalite, a mesoporous magnesium carbonate, as an approach to increasing the aqueous solubility of poorly soluble drugs. International Journal of Pharmaceutics, 472(1-2), 185-191.
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