This paper explores the perception of pain in an individual concerning diverse aspects. As pain is the most common reason for seeking medical attention, the therapist needs to be familiar with the factors that influence pain perception and treatment approaches. The factors discussed in this paper are sociocultural, behavioral, psychological, gender, religion, personality, age, coping and genetics etc. In former literature, the pain was only considered to take a physiological form, however, was later revealed to also have psychological factors which could also have an impact on pain perception. Many theories and models supported this idea, one of which was proposed by Skevington in 1995. Hence, health care providers must approach a client holistically considering all the factors.