This paper presents the analysis of confinement loss and dispersion of Multi-Core Fiber (MFC) by varying the structural parameters like wavelength, diameter of holes and pitch length. The different geometries of Multi-Core Fiber used for this analysis are Hexagonal, Octagonal and Decagonal structures. The simulation is done by doping few inner ring holes of the MCF with different liquids having refractive index lower than that of the actual core. The calculation of confinement loss and dispersion is done in COMSOL Multiphysics software while the graphs are plotted in MATLAB. It has been observed that variation of structural parameters has been found to cause change in confinement loss and dispersion. After comparing these three structures, it is seen that hexagonal structure shows a better outcome than others.