With the increase in industrialisation, increased production rate, high efficiency, and optimisation have become a priority. Meeting quality requirements has become equally important as meeting production requirements. Safety is of interest to every individual and group. Hence, nowadays safety management has become important part of industrial management. The primary interest in this study is the quality and productivity improvement along with safety improvement. Through exhaustive literature review it has been identified that till now no work has been done to identify and statistically establish the reliability and validity of CSF for Quality, Productivity and Safety interrelationship for overall improvement of manufacturing industries. This work aims to fill this gap. Empirical data were collected through a structured questionnaire from 450 respondents belonging to different manufacturing industries. The analysis was conducted using SPSS as tool. The findings indicate that there exists a positive relationship between quality, productivity, and safety for overall performance improvement. The manufacturing sector plays a vital role in the economic growth of any nation. Thus, the importance and need to evaluate this sector is justified.