Lower respiratory tract infection is common among children. This will interrupt the children breathing pattern and cause breathing difficulty. This study was carried out to assess the effectiveness of Strelinikova breathing exercise on reduction of respiratory signs among preschooler with Lower respiratory tract infection. The study was based on Callista Roy's adaptation model of nursing theory. Quasi experimental pretest and posttest control group design has been adopted. The study was conducted in Agasthiya Muni Child Care Centre, Vellamadam. Purposive sampling technique was adopted. A sample of 30 was selected on the basis of inclusion criteria, from 15 experimental group, 15 control group preschooler with lower respiratory tract infection. The data collection tool included demographic variables and Modified severity of exacerbation grade scale and oxygen saturation. Strelinikova breathing exercise was demonstrated by investigator to the experimental group for 10 - 15 minutes. This was followed for five days and was given thrice a day. Posttest was conducted on 5^th day in both experimental and control group. In part I in the experimental group the pretest mean respiratory sign score was 6.06 with SD 1.66 and in the control group, the mean score was 5.86 with SD 1.60. The mean difference was low and statistically not significant. That is both groups are equal in the pretest level of respiratory signs. In the experimental group, posttest means respiratory signs score was 3.66 with SD 0.72 and in the control group was 4.93 with SD 1.27. The mean difference was high and statistically significant. That is the Strelinikova breathing exercise was effective in part I respiratory signs. In part II in the experimental group, the pretest mean respiratory sign score was 2.60 with SD 0.51 and in the control group, the mean score was 2.46 with SD 0.52. The mean difference was low and statistically not significant. That is both groups are equal in the pretest level of respiratory signs. In the experimental group, posttest means respiratory signs score was 1.33 with SD 0.52 and in the control group was 1.83 with SD 0.45. The mean difference was high and statistically significant. That is the Strelinikova breathing exercise was effective in part II respiratory signs. The findings revealed that the administration of Strelinikova breathing exercise has a better effect in reducing lower respiratory tract infection.