Nowadays, Metal-Oxide-Semiconductor Field-Effect Transistor (MOSFET) has found its usage in each and every field. Researchers are always trying to redesign the circuit by using Complementary Metal-oxide Semiconductor (CMOS) technology which gives the efficient circuit of MOSFET. To design sensor for aerospace application, that it uses sigma delta Analog to Digital Converter (ADC). To design difference amplifier, high gain operational amplifier plays a key role. The proposed work modifies the differential amplifier design using R-2R technique and also uses reduced operational amplifier. Thus it outcomes the consumption of energy and frequency reduced due to optimized op-amp design.