Depression is a broad spectrum disorder, with multitude of concerns, varying from biological, psychological, social, and even from spiritual perspective. Depressive disorders create a disabling condition for an individual which negatively impacts the social, occupational, and interpersonal functioning. The compounding effects of numerous disabling factors reduce the quality of life of a depressive patient. Various measuring instruments have been identified for better understanding of the level of quality of life, and even ego resilience of a depressive patient. A person with higher levels of resilience will have lesser chances of suffering from depressive symptomatology. The complexity and diversity in understanding these both concepts has led to neglect and failure in appropriate interventions. Nurses have a major responsibility in assessment as well as recognition of such deficiencies in depressive clients, with a view to intervene efficiently. The article is attempting to organise the impact, existing measures, shortcomings, and strategies to overcome the shortcomings, with regard to resilience and quality of life among people with depression.