The women of today face not only diseases of genetic origin, but more importantly, diseases that arise from the poor habits that society has developed. As former Prime Minister Jawaharlal Nehru said, “You can tell the condition of a nation by looking at the status of its women” (Chankapa et al., 2011). The study aimed to investigate knowledge and attitude about cervical cancer and HPV vaccines among the age group between 14 to 30 years in urban community of Maharashtra. The study adopted a quasi-experimental “one group” with 'pre-test' and 'post-test' approach with convenient sampling technique. A sample of 50 women of age group 14 to 30 years was selected. The effect of structured teaching programme consisting of cervical cancer and HPV vaccine are evaluated. Descriptive statistics used and pre-test, post-test analysis was done. Findings: The pre-test, post-test study revealed significant differences seen in knowledge and attitude between the pre-test and post-test. In the pre-test, 44% had good knowledge and 60% agreed in the attitude. Whereas post-test 62% had very good knowledge and strongly agreed in the attitude questions. The results show that there is a difference in knowledge and attitude by 18% and 2%, respectively, which also suggest that a structured teaching programme was effective. The study shows that pre-test scores were increased after giving structured health teaching regarding cervical cancer and HPV vaccine. This increase in post-test scores suggests that education may increase knowledge of cervical cancer and HPV vaccine.