Polycystic Ovarian Syndrome is a hormonal disorder causing enlarged ovaries with small cysts on the outer edges. It is rising among Indian women, where out of every 10 women one woman is affected, among them teenage girls are affected more than the others. It is curable, if found early, for early detection, the teenagers should have an awareness about Polycystic Ovarian Syndrome. The objective of the study was to determine the effectiveness of structured teaching programme on Polycystic Ovarian Syndrome among nursing students. The present study was adopted with a quantitative approach with pre-experimental; one group pretest-posttest design. The sample consisted of 30 nursing students in Kanyakumari District, selected by using purposive sampling technique. The researcher used two data collection instruments. The result reveals that the pre-test mean score of knowledge level was 34.8±13.23 and post-test was 76.6±5.4. The mean reduction of pain was 2.613±15.99 and it was statistically highly significant at P<0.00001 level. This study supports the need of education for adolescent girls in improving their knowledge level towards Polycystic Ovarian Disease (PCOD).