Computer aided Design (CAD), 3-D modeling and engineering analysis can be efficiently applied in many research and industrial fields including aerospace, defense, automobile, consumer product, and many other product development. These efficient research and engineering tools apply computer-assisted technology to perform 3-D modeling on different products, support geometrical design, make structural analysis, assist optimal product design, create graphic and engineering drawings, and generate production documents. This technology helps scientists and technical professionals efficiently import basic geometrical inputs and design information to accelerate the engineering design process, with well controlled design documents, to support production and manufacturing processes. Currently these research and engineering tools have been playing more and more important roles in different business and enterprises due to its financial and technical importance in business, industrial, engineering, and manufacturing applications. The computer aided modeling and analysis allow more sophisticated, flexible, reliable, and cost-effective manufacturing control. Automation and automated production system are to use control system to reduce human labor intervention during manufacturing processes and put strong impact on industries. Automation and automated system design not only raise the production rate but also control the product quality. It can effectively keep consistent product quality, reduce production lead time, ease material handling, maintain optimal work flow, and meet the product requirement by controlling the flexible and convertible manufacturing / production processes. Computer aided modeling and engineering design can quickly simulate and model the automated production systems and reduce product development life cycles. Computer aided engineering solution can improve and optimize the industrial integral processes in design, development, engineering analysis, and product manufacturing. Also the present and future economic globalization requires cost-effective manufacturing via highly industrial automation, efficient design tooling, and better production control. This keynote lecture describes the technology, types, and general applications of these research and engineering tools through conceptual analysis and real case study in computer aided design, 3-D modeling, and engineering analysis. Some new product systems, developed by author, are introduced to help readers understand how to design and develop new product systems by using computer aided design, engineering analysis, and prototype experiment. The case studies include design and development of green / sustainable energy systems (solar still, solar panel, and wind power energy), biomedical and surgical instruments, energy-saving cooling system, automated and high speed assembly system (highly viscous liquid filling and chemical gas charging), robotic system for industrial / automated manufacturing, magnetic sealing system, and high speed packaging machinery system. Multiple engineering case studies in this keynote lecture aim at the introduction, study and analysis by using computer aided modeling and engineering analysis for industrial and engineering applications. All these newly developed product systems have also been verified by prototyping and testing to validate the functionality of these new systems. Both computer aided analysis and experimental methodologies introduced in this keynote lecture show close results that positively show the feasibility and credibility of analytic and experimental methodologies introduced in this keynote lecture.