Adolescent account for almost 20.9% of the country's population. Roughly, in India, for every two women newly diagnosed with breast cancer, one is dying of it. The high mortality in developing countries is due to lack of awareness, early detection, and poor access to treatment facilities. To make awareness among adolescents a pre-experimental research design was selected to evaluate the effectiveness of VATM (Video-Assisted Teaching Module) on knowledge of adolescent girls regarding breast self-examination to prevent breast cancer in Roland Junior College, Ankuli, Berhampur, by using convenient sampling technique. Results show that highly significant difference was found between pre and post-test knowledge score and no significant difference was found between knowledge score with their selected demographic variables. The study and prepared video is very useful for the Nurses to teach patients and women in their community regarding the steps of BSE (Breast Self Examination).