The clinical status of the tissue can be diagnosed by measuring its biological electrical impedance (Z), which acts in general as a parallel connection of capacitive and resistive loads. It has a complex value which is strongly related to the effects of different biological factors and diseases. In this experimental clinical work, the electrical LCR-meter was programmed and used for the measurements of the spectral skin bio-impedance (Z) and its detailed components as a noninvasive technique for skin cancer diagnosis. The examinations of nine volunteer patients confirmed that the results of the skin bio-impedance measurements can be used as an important factor to check out whether the infected area is a basal cell skin cancer (BCC).