Hyderabad is the 5^th largest city in India. It has twin cities Viz., Hyderabad and Secunderabad with its suburbs extending up to 16 miles. The core cities, together with its nine surrounding municipalities are covering an area of 500 square km. The Hyderabad city discharges about 600 million litres per day untreated sewerage water into Musi River. A stretch of 13 Km from Nagole /Uppal IDA to Prathap Singaram is chosen as the study area as it is surrounded by more than 25 industries and their effluents are directly drawn into Musi River (IOSR-JESTFT 2012) [1]. The Musi River water is used for irrigation during its course of travel which leads to adverse effects on both flora and fauna. The bore well water samples in the radius of 1 km are collected at ten distant places at certain intervals along the Musi River to know the quality parameters. The collected samples are tested in the Telangana State Ground Water Department (GWD) to access the quality. The chemical analyses data for both Musi River and bore well water samples are obtained from the GWD for study and interpretation including its impact. Rainfall data of Uppal Mandal for 10 years beginning 2005 onwards is also collected from weather station of Acharya N G Ranga Agricultural University, Rajendra Nagar, and Hyderabad for further studies. It is worthy to note that only Nitrates are recorded as high in all the samples when compared to the BIS standards, otherwise, the remaining parameters are in the normal range [4]. Among 10 stations, 8 stations are having high Nitrate (NO₃ as N) values in which the highest Nitrate value of 35.40 mg/lts is observed from station-5 of R-Krishnaiah Nagar (V), Hayath Nagar (M) and station-9 i.e. of Submerged Well situated within the radius of 1 km from Thimmaiguda (V), Ghatkesar (M). Further, it is observed that bore well water samples of 1, 3, 6 and 9 are witnessed with moderate concentration of EC, TDS, Cl, Cam TH and NO₃ whereas Musi River sample collected near R-Krishnaiah Nagar is witnessed with moderate to high concentrations of EC, TDS, Cl, Na, K, TH and NO₃ . The objective of the paper is to minimize the impact of effluents and industrial wastes discharged by the industries by establishing more treatment plants.