To keep pace with revolutionary advancements in VLSI design, a Programmable System on Chip (PSoC) has been developed to monitor ECG signals, utilizing innovative Analog and Mixed Signal (AMS) technology. Electrocardiographic signals are very weak and have ultra-high impedance, making traditional analog amplifiers unsuitable. The AMS-based PSoC devices from Cypress Semiconductors demonstrate the capability to provide a suitable solution for this issue. The analog section of the PSoC device CY8C55 has ultra-high input impedance. Therefore, by deploying the on-chip resources of this device, an embedded system has been designed to detect and monitor ECG signals. This paper interprets the issues related to the design and validation of both on-chip hardware and embedded firmware. Using electrodes placed only off the chip, the signals are read into the chip with an appropriate reference level. The on-chip PGAs are configured for signal extraction. The analog signals are digitized with 10-bit resolution and then digitally filtered with a low-pass filter configured for Fc = 150 Hz. The signals are recorded in real-time on the DSO. Upon investigating the ECG signals monitored on the DSO, it can be concluded that the current SoC is highly suitable for medical applications.