To keep pace with the revolutionary advancement taking place in the field of VLSI design, a Programmable System on Chip (PSoC) is designed to monitor the ECG signal, wherein an innovative Analog and Mixed Signal (AMS) technology is deployed. The electrocardiographic signals are very weak and are available at ultra high impedance for which traditional analog amplifiers found unsuitable. The AMS based PSoC devices from Cypress Semiconductors exhibit the capability to provide suitable solution on this problem. The analog section of the PSoC devices CY8C55 has ultra high input impedance. Therefore, deploying on chip resources of this device, an embedded system is designed on chip to detect and monitor the ECG signal. The issues of designing and validation of both on chip hardware and embedded firmware are interpreted in this paper. Employing the electrodes, only off the chip, the signals are read into the chip with proper reference level. The on chip PGAs are configured for extraction of the signal. The analog signals are digitized with 10 bit resolution and then digital filtered with low pass filter configured for Fc= 150Hz. The signals in real time are recorded on the DSO. On investigation of ECG signal monitored on the DSO, it can be said that the present SoC is mostly suitable for medical applications.