The challenges facing the supply of potable water and the environmental nuisance that wastewater discharge is provoking in Nigeria cannot be underestimated. While most of the previous studies focused on industrial wastewater treatment, this study identified the challenges of domestic wastewater reclamation and reuse in Nigeria; assessed the methods of reclaiming domestic wastewater and examined the effects of reclaiming and reusing domestic wastewater in Nigeria with a view to providing information that will enhance the sustainable reuse of wastewater in Nigeria. The study used primary and secondary data. Primary data was collected from seven selected wastewater treatment plants in different geopolitical zones and Abuja municipal. It was sourced using site visits and google forms. Data collected include the challenges of reclaiming domestic wastewater, the method of reclamation, level of treatment operating and current ways of reusing domestic wastewater in their organization/estate, knowledge of domestic wastewater reclamation and reuse, ways in which reclaimed domestic wastewater can be reuse in Nigeria and effects of reclaiming and reusing domestic wastewater in Nigeria. The data were analyzed using frequency, percentages, content analysis and mean score (MS). Finding reveals that the major challenges of wastewater reclamation and reuse in Nigeria are: cost (it is capital intensive), erratic power supply, shortage of skilled personnel, sewage collection problem and ineffective public sewer while the methods of reclamation in use are activated sludge (extended aeration), anaerobic digestion, oxidation ponds and membrane filtration respectively. Furthermore majority of the wastewater treatment plant employed the tertiary level of treatment. The result of mean score showed that the effects of reclaiming and reusing domestic wastewater in Nigeria were to prevent breakout of waterborne diseases (MS=4.93), to prevent environmental pollution (MS=4.88) and rapid urban population growth (MS=4.85). The study also revealed that agricultural purposes should be the major way of reusing wastewater in Nigeria based on the analyzed data .The study concluded that breakout of waterborne diseases and environmental pollution are the major reasons why Nigeria should reclaim and reuse the domestic wastewater.