For a river management it is necessary to identify the vulnerability and their effects on the morphology of river bed and riverside lands. This study aims to focuses on the identification of vulnerable zone with erosion and shifting of the 22 km stretch River Yamuna along Delhi between Wazirabad Barrage and Okhla Barrage. An attempt has been made to use GIS and RS techniques for change detection of river courses for past and present geographical data sources of river courses. Using three dry season satellite images of Landsat MSS (60 m) for 1980 and 1989 and Landsat8 (30 m) for 2017 largely pre and post construction of major barrages and bridges have been considered. The bank line movement rates (m/yr) of the river were analyzed under three periods: 1980-1989, 1989-2017 and 1980-2017. The result indicates that the downstream of Wazirabad barrage and upstream of Okhla barrage have changed significantly due to varying reason of erosion, accretion and construction activities. Rate of shifting in both the upstream of Okhla barrage and downstream wazirabad barrage is more in between 1980-1980 as compared to 1989-2017. The rate of shifting between 1980-1989 in downstream of wazirabad barrage was 3.6 times more than between 1989-2017. The rate of shifting between 1980-89 in upstream of Okhla barrage was 3.4 times more than between 1989-2017. The most effective factors in morphological changes are the changes in regime because of dam construction, reduction of runoff, and accumulation of sediment loads on the riverbed.