The processes of humidification and dehumidification (HD) are based on the fact that air can be mixed with quantities of vapor. When airflow is in contact with salt water, air extracts a certain quantity of vapor. On the other hand, the distilled water is recovered by maintaining the humid air in contact with cooling surfaces. A wide range of thermal energy including solar, geothermal, exhaust gases, and fossil fuel may be used to operate HD desalination systems. These systems are suitable for arid areas, and when the demand for fresh water is decentralized. In the present work, the influence of the feed salinity and air flow rate on the thermodynamic performance is analyzed. It is found that both the performance ratio and the productivity decreases with the increase in the salinity of the feed water. A parametric study is performed to find the effect of the air flow rate on the productivity and the performance ratio of the system. It is found that both the productivity and the performance ratio decreases with the increase in the air flow rate.