If the building structure is not properly designed and constructed according to IS codal provisions, it causes more damages and destruction of the human property, and also loss of living creatures. It is recommended that the structure should be properly analyzed, designed, and constructed with good quality material, so it has become safe to resist the earthquake load. Seismic analysis of the building structure is carried out to determine the seismic response of structure by using Time history analysis method. In this research paper, seismic analysis of a multi-storey building structure is done. The response of the building is analyzed for various seismic loading. ETABs (Extended Three-dimensional Analysis of Building System) software is used for modeling of the building. By using time history method, we can analyze the base shear, displacement, and storey drift of the building. The comparison is done with equivalent static analysis also to know the variation in results. Matlab program is also used for performing the Time history analysis of the building using Elcentro seismic data.