Optimization of Microencapsulation for Biodegradable Polymers using Response Surface Methodology

Yashwant P. Bhalerao*, Robinson Timung**, Sushma Gawai***
*-** Lecturer, Department of Chemical Engineering, Government Polytechnic, Daman, India.
*** Lecturer, Department of Chemistry, Government Science College, Pardi, India.
Periodicity:January - March'2018
DOI : https://doi.org/10.26634/jms.5.4.13972


Microencapsulation has wide applications in medical, pharmaceutical, and food industries. The parameters affecting the microencapsulation process has to be optimized in order to achieve high efficiency of encapsulation. This study has the objectives of optimizing the process parameters involved in the encapsulation process of Metformin into Guar gum. The process parameters affecting the microencapsulation process of biodegradable polymers, viz. rotation speed (800-1200 rpm), drug to polymer ratio (0.2, 0.4, 0.6), and reaction time (30-90 min) were evaluated and optimized with Response Surface Methodology (RSM) using three level-three factor Central Composite Design (CCD). The P-value <<0.0001 with R2 = 0.9979 showed highly significant model. The results obtained revealed that particle size increases with increasing drug to polymer ratio and reaction time whereas speed of rotation (rpm) has a negative effect towards the particle size formation. The interaction between the speed of rotation (rpm) and reaction time has been found highly significant, however a minuscule interaction between drug to polymer ratio and speed of rotation (rpm) as well as between drug to polymer ratio and reaction time has been observed. A particle size of 24.73 ± 0.21 μ was obtained at the optimum condition of the process variables generated by the model which was 1156 rpm, drug to polymer ratio of 0.37 and reaction time of 89 minutes.


Microencapsulation, Polymers, Biodegradable, Response Surface Methodology, Central Composite Design

How to Cite this Article?

Bhalerao,Y.P., Timung,R., and Gawai,S. (2018). Optimization of Microencapsulation for Biodegradable Polymers using Response Surface Methodology. i-manager’s Journal on Material Science, 5(4), 40-46. https://doi.org/10.26634/jms.5.4.13972


[1]. Al Haushey, L., Bolzinger, M. A., Bordes, C., Gauvrit, J. Y., Briancon, S. (2007). Improvement of a bovine serum albumin microencapsulation process by screening design. International Journal of Pharmaceutics, 344(1-2), 16-25.
[2]. Deshmukh, R., & Naik, J. (2014). Study of formulation variables influencing polymeric microparticles by experimental design. ADMET and DMPK, 2(1), 63-70.
[3]. Freitas, S., Merkle, H. P., & Gander, B. (2005). Microencapsulation by solvent extraction/evaporation: Reviewing the state of the art of microsphere preparation process technology. Journal of Controlled Release, 102(2), 313-332.
[4]. Guan, X., & Yao, H. (2008). Optimization of Viscozyme Lassisted extraction of oat bran protein using response surface methodology. Food Chemistry, 106(1), 345-351.
[5]. Joglekar, A. M., & May, A. T. (1987). Product excellence through design of experiments. Cereal Foods World, 32(12), 857-868.
[6]. Kale, V. V., Lohiya, G. K., Rasala, T. M., & Avari, J. G. (2010). Optimization of compressed guar gum based matrix system: Influence of formulation on change of drug (s) release rate. International Journal of Pharmaceutical Sciences Review and Research, 3(1), 12-15.
[7]. Malakar, J., Sen, S. O., Nayak, A. K., & Sen, K. K. (2012). Formulation, optimization and evaluation of transferosomal gel for transdermal insulin delivery. Saudi Pharmaceutical Journal, 20(4), 355-363.
[8]. Montgomery, D. C. (2005). Design and Analysis of Experiments: Response Surface Method and Designs. John Wiley and Sons, Inc. New Jersey.
[9]. Nayak, A. K., Pal, D., Pradhan, J., & Hasnain, M. S. (2013). Fenugreek seed mucilage-alginate mucoadhesive beads of metformin HCl: Design, optimization and evaluation. International Journal of Biological Macromolecules, 54, 144-154.
[10]. Priyanka, & Mishra, D. N. (2013). Compatibility testing of Guar Gum with metformin hydrochloride. International Journal of Pharma and Bio Sciences, 4(2), 39-44.
[11]. Silva, P. I., Stringheta, P. C., Teófilo, R. F., & de Oliveira, I. R. N. (2013). Parameter optimization for spray-drying microencapsulation of jaboticaba (Myrciaria jaboticaba) peel extracts using simultaneous analysis of responses. Journal of Food Engineering, 117(4), 538-544.
[12]. Singh, J., & Sharma, A. (2012). Application of Response Surface Methodology to the modeling of cellulase purification by solvent extraction. Advances in Bioscience and Biotechnology, 3(04), 408-416.
[13]. Strand, B. L., Gåserød, O., Kulseng, B., Espevik, T., & Skjåk-Bræk, G. (2002). Alginate-polylysine-alginate microcapsules: Effect of size reduction on capsule properties. Journal of Microencapsulation, 19(5), 615-630.
[14]. Wadher, K. J., Kakde, R. B., & Umekar, M. J. (2011). Study on sustained-release metformin hydrochloride from matrix tablet: Influence of hydrophilic polymers and in vitro evaluation. International Journal of Pharmaceutical Investigation, 1(3), 157-163.

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