JNUR_V6_N3_RP1 Rozina Shazad Ramji Muhammad Yahya Noori Asima Faisal Journal on Nursing 2231 – 4504 6 3 5 16 Postpartum Depression, Working Mother, Non-Working Mother, Mother Infant Interaction, Developing Countries Parenthood is a transition period, characterized by significant change in a new parent's life, which is called post-partum period. It's a time in which woman undergoes the transition of motherhood to parenthood. It is extremely important to manage the postpartum period very effective if not, then mother may go through postpartum depression stage. The Cross Sectional Study design was used to determine whether there is a difference in the rate of PPD between working and non-working mothers as well to determine whether there is a relationship of associated factors of postpartum depression among working and non-working women. The data were collected using the validated EPDS & PNRQ Tool and a General Questionnaire. A Chi square test was used to determine the difference in the rate of PPD between both working and non-working mothers during the postpartum phase. According to Edinburgh postnatal depression scale, no depression was found in 202 participants of non-working women (80.8%) whereas in working women only 89 participants reported no depression (35.6%) and this difference was found to be statistically significant at P<0.001. The study findings revealed that there is increase in postpartum depression in working mothers than non-working mothers; therefore, early intervention could be planned in the form of group teaching sessions which will help new mothers to develop a friendship network to support with the challenges of caring for her preterm infant. August - October 2016 Copyright © 2016 i-manager publications. All rights reserved. i-manager Publications http://www.imanagerpublications.com/Article.aspx?ArticleId=8257