This article is focused on the major features of Orem's self-care theory, grand theory, and Katharine Kolcaba's comfort theory, a middle-range theory Kolcaba developed in the 1990s. It is a middle-range nursing theory designed for nursing practice, research, and education. According to her theory, patient comfort exists in three forms, relief, ease, and transcendence. These comforts can occur in four contexts: physical, psycho-spiritual, environmental, and sociocultural. Dorothea Orem established the Self-Care Nursing Theory, often known as the Orem Model of Nursing, between 1959 and 2001. Orem's theory comprises three theories, the theory of self-care, the theory of self-care deficit, and the theory of the nursing process. The article is based on a real-life scenario. The aim of this paper is to compare the mentioned theorists, their impacts on the outcomes, and their relationships with the clinical scenario in their own approaches.