When a structure is subjected to earthquake forces, vibrations are setup in the structure leading to severe damages to the structure and results in loss of property and life. Now a days, keen attention is given to research and development of vibration control devices to mitigate the seismic effects. The present duty of civil engineer is to discover earthquake resisting design approach to reduce structural damages. The basic technology used to protect the structure from damaging earthquake effects is “base isolation”. The base isolation system decouples the super-structure from the substructure by means of flexible devices through which seismic energy is dissipated. In the present context G+15 storey structure situated in zone V is modeled and analyzed using ETABS-2017 software by providing different base isolation systems namely a) RC structure having fixed base b) RC structure with Fluid Viscous Damper (FVD) and Lead Rubber Bearing (LRB). Response of the structure is studied in terms of story displacement, story drift, base shear, natural time period and design lateral forces. It is found that the provision of Fluid Viscous Damper (FVD) and Lead Rubber Bearing (LRB) in a same structure shows better performance in story displacement, base shear, story drift, natural time period and design lateral forces as compared to fixed base model.