JME_V4_N3_RP3 Sourav Acharya Apurbba Kumar Sharma Journal on Mechanical Engineering 2249 - 0744 4 3 15 20 Microchannels, Micromixing, Mass Fraction, Mixing Length, Reynolds Number Mixing in microfluidics has become a pivotal issue in the field of Microelectromechanical systems. Mixing can be enhanced in microchannels by complicating the geometry of the channel. Different microchannel structures have been studied to analyse the mixing performance. In this paper, a numerical simulation has been done to compare the mixing performance of straight, serpentine, and three-dimensional serpentine microchannels with the help of ANSYS Fluent. The study shows that due to chaotic advection caused by the formation of secondary flows, the 3D serpentine microchannel shows better mixing performance. May - July 2014 Copyright © 2014 i-manager publications. All rights reserved. i-manager Publications http://www.imanagerpublications.com/Article.aspx?ArticleId=2726