JIP_V2_N3_RP2 K. Rajkumar V. Padmaja Journal on Image Processing 2349-6827 2 3 14 18 Polarimetric Imaging, Optical Signature, Tissue Imaging Polarimetric imaging is an emerging technique that uses polarized light to probe the acceptance of the tissue. Basically, tissues are mostly accepted by the clinicians by their chemical processing which takes some time to get the results. Polarization imaging techniques are utilized to understand the variation of polarization properties of optical light which passes through the tissue. The obtained images that are obtained when optical light passes through tissue helps the clinicians to understand and assess the tissue properties and provide knowledge about the functioning of the tissue. In this work, the tissues collected are used for the experimental purpose of tissue interaction with the optical light and is used whether the imaging results of this experiment can be used to study its properties by the signature matrix of the tissue. If the recognizable Mueller Matrix is obtained from this process with rotating optics, then we can understand the polarization variation in the tissue through a novel pixel by pixel analysis technique and via the normalized signature matrix of the tissue. July - September 2015 Copyright © 2015 i-manager publications. All rights reserved. i-manager Publications http://www.imanagerpublications.com/Article.aspx?ArticleId=3601